Abstract To broaden the substrate scope of microbial cell factories towards renewable substrates, rational genetic interventions are often combined with adaptive laboratory evolution (ALE).However, comprehensive studies enabling a holistic understanding of adaptation processes primed by Support rational metabolic engineering remain scarce.The indus
Abstract Among an assortment of genetic variations, Missense are major ones which a small subset of Cybercel them may led to the upset of the protein function and ultimately end in human diseases.Various machine learning methods were declared to differentiate deleterious and benign missense variants by means of a large number of features, including
The optical coupling efficiency of surface plasmon resonance (SPR) based sensors is theoretically investigated from the first principle.Analytical expressions for the instantaneous electric flux lines associated with the TM modes of a three-layer dielectric-metal-dielectric (DMD) waveguide structure are calculated.It is shown that these electric fl